Wilmingtons Latest Legal Notices Week of September 23 2018

first_imgWILMINGTON, MA — Below are the latest legal notices related to Wilmington, published during the week of Sunday, September 23, 2018:181163 — Vibert — 12 Ox Bow Drive Wilmington181237 — Babine — 6 State Street Wilmington181252 — Boudreau Estate Wilmington181253 — Forrest Towing — 2007 Saturn VUE181260 — Wilmington Conservation Commission — 16 Kenwood Avenue181263 — Fitzmeyer Estate Wilmington181267 — Wilmington Board of Appeals — Nouria Marciello181271 — Wilmington Board of Health — Changes to Regulations(NOTE: The above public notices is from MassPublicNotices.org.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedWilmington’s Latest Legal Notices (Week of September 1, 2019)In “Government”Wilmington’s Latest Legal Notices (Week of August 18, 2019)In “Government”Wilmington’s Latest Legal Notices (Week of August 25, 2019)In “Government”last_img read more

Was Hoogerbeets right Earthquake hits Greece after dire warning citing planetary alignment

first_imgRepresentational image | ReutersA couple of days back, Frank Hoogerbeets, a self-proclaimed seismic researcher had shockingly claimed that a powerful earthquake will jolt the planet in the final days of March. The researcher who runs the seismic prediction website ‘Ditrianum’ also warned that the earthquake will measure more than 8 on the Richter scale.Interestingly, in the same timeline, an earthquake measuring 5.3 in the Richter scale hit Greece on March 30. As per the National Observatory, no casualties have so far been reported due to the earthquake and they revealed that the quake had a depth of around 14km and epicentre in the Gulf of Corinth, 200 kilometers northwest of Athens.”It was a strong earthquake felt in the general area and in Athens as well. The situation is under control and we are monitoring it. There are many fault lines in the Gulf of Corinth”, Efthymios Lekkas, head of Greece’s earthquake planning and protection agency, told state TV ERT.The recent quake which hit Greece has made many conspiracy theorists believe that Frank Hoogerbeets’ predictions are authentic and a megaquake may hit the planet in the coming days. Hoogerbeets had claimed that the earthquakes are the result of a critical planetary alignment where Mercury, Earth, Venus, Neptune and the Sun line up together.Hoogerbeets had previously revealed several times that he is using a sophisticated system named solar system geometry index (SSGI) to predict potential earthquakes. Hoogerbeets believes that critical planetary geometry will destabilize the tectonic plates on earth, thus causing a rise in seismic activities.However, experts have dismissed his claims every time stating that no current technology is capable of predicting earthquakes with precision. These seismic experts believe that a small earthquake might be a foreshock which might be signaling a megaquake, but we do not know it is a foreshock until the big one happens.last_img read more

Prabhas underrates Vijay Devarakonda A publicity stunt for Shahid Kapoors Kabir Singh

first_imgPrabhas, Vijay Devarakonda and Shahid KapoorCollage of photos taken from Twitter and FacebookReports of Baahubali actor Prabhas underrating Vijay Devarakonda, while praising Bollywood actor Shahid Kapoor, are said to be part of an effort to drum up publicity for Kabir Singh, a remake of Arjun Reddy.Talking to the media, hair stylist Hakim Aalim said that he showed the teaser of Kabir Singh to Prabhas on the sets of Saaho in Hyderabad. The Baahubali actor was impressed with Shahid Kapoor. Later, Hakim helped the actor speak to the Bollywood star over phone. In his conversation, Prabhas said that Shahid looked better than Vijay Devarakonda in the Hindi remake of Arjun Reddy.Hair stylist Hakim Aalim’s statement created a lot buzz on the social media over the weekend. Many fans of Vijay Devarakonda were left red faced by Prabhas’ remark. Some upset fans expressed their outburst against the Darling star for underrating their favourite actor in a bid to praise Shahid Kapoor.But now, a source close to Prabhas says this act was an overdrive by Shahid Kapoor’s publicity machinery. He claims that there is no proof for the phone conversation between these two actors. Even if they had spoken over phone, it is their personal stuff and it should not be put on the public domain. However, the PR of the Bollywood actor has used it for the publicity of Kabir Singh, which is unethical.”It is not likely that Prabhas would say that the remake looks better than the original. When and where did he say that? And to whom? The report quotes Prabhas’ hairstylist saying that he heard Prabhas praising Shahid Kapoor on the phone and that apparently, he heard Prabhas say that Kabir Singh looked better than Arjun Reddy,” Deccan Chronicle quoted the source as saying.”Firstly, it is extremely unethical to eavesdrop on a private conversation between two individuals (in this case, Prabhas and Shahid) and then put it on a public platform as news. Secondly, did this telephone conversation between Shahid and Prabhas really happen? We don’t know that! Thirdly, why are the makers of Kabir Singh encouraging comparisons with the original?” argued the source.last_img read more

Top Sri Lankan officials deliberately withheld intelligence on attacks Minister

first_imgExplosion at St. Anthony’s Church at KochchikadeTwitter [Representational Image]Senior officials deliberately withheld intelligence about possible attacks on Sri Lanka, where a rash of suicide bombings on Easter Sunday killed at least 359 people, the leader of parliament said on Wednesday.”Some top intelligence officials hid the intelligence information purposefully. Information was there, but the top brass security officials did not take appropriate actions,” Lakshman Kiriella, who is also minister of public enterprise, told parliament.He said information on possible suicide attacks on churches, hotels and politicians were received from Indian intelligence on April 4 and a Security Council meeting was chaired by President Maithripala Sirisena on April 7, but the information was not shared more widely.”Somebody is controlling these top intelligence officials,” the minister said. “The Security Council is doing politics. We need to investigate into this.”Separately, Sarath Fonseka, former army chief and minister of regional development, told parliament he believed the attacks “must have been planned for at least 7-8 years”.last_img read more

Hasina asks party men not to get defeated

first_imgBangladesh Awami League (AL) president and prime minister Sheikh Hasina addresses her party’s third phase of the special extended meeting at her official Ganabhaban residence in the city on Saturday. Photo: BSSApparently concerned about the ruling party’s chances in the next general elections, Bangladesh Awami League president, prime minister Sheikh Hasina on Saturday asked her party men to remove differences within the party.She said the party leaders and workers must support the ones who would be given ‘boat’, the AL’s election symbol symbol, in the next parliamentary polls.”We cannot afford to lose a single seat — we have to show this kind of attitude,” Hasina said addressing the party’s third phase of the special extended meeting at Gonobhaban in the city on Saturday.The AL chief cautioned the party leaders and workers as BSS quoted her as saying, “You have to remember that the forthcoming election would be much harder than ever.”She urged the party men to organise AL as well as its front organisations and go to the doorstep of the people to seek their votes in the next general election.“Awami League is the only political party in the country, which feels for the people and works for their welfare,” she said urging the party men to wage a rigorous campaign among the people to make them understand this message.AL general secretary Obaidul Quaader gave the welcome address while office secretary Abdus Sobhan Golap placed the motion of condolence. Publicity secretary Hasan Mahmud and deputy publicity secretary Aminul Islam conducted the meeting, reports the state news agency.The prime minister said the rural economy has been boosted up and the people have started getting a good result with their higher income side by side with enjoying the facilities of digital Bangladesh and getting scope to live better as Awami League remains in power.No political party except Awami League has ever done anything for the peasants and the working class people, she said adding, “Awami League is pledged bound to ensure that all people have homes and they do not suffer from starvation or are deprived of healthcare services and education,” she said.The prime minister called upon the party leaders and workers to plead to the people so that they give votes to the Awami League candidates as they had given in the past. At the same time, she asked the party followers to sink all internal conflicts and fight saying ““Leaders and workers have no scope to show negligence in any single constituency which may lead to their defeat and might damage the scope of forming the government,” she said.Referring to her government’s initiative for trial of the war criminals of 1971, the prime minister said this process would be stopped if Awami League cannot come to power again.“They will carry out attacks on the people, their homes and property, increase poverty rate, reduce literacy rate, suspend safety net programs and all development works like they have done in past if they come to power,” she said.So, you have to make the organization stronger to work for the people to change their lots, she said.Office bearers and leaders representing different units of Awami League at districts, upazila, pourasabha and union levels from Rangpur, Khulna, Dhaka and Mymensingh divisions took part in the third-phase extended meeting of the party.Recalling the atrocities of BNP and Jamaat ahead of the general election in 2014, the prime minister said they burnt people alive and set fire on public properties indiscriminately in the name of movement to foil the polls.But, they could not foil the election as the people stood against their evil design; she said adding that Awami League works for the people as they are the main strength of the party.Sheikh Hasina reminded her workers that the people may go to oblivion if a thing is not told to them repeatedly. The forces which are even have no faith in the independence, would do nothing for the people, she said. “So, you haveto go to the people and tell them those things constantly,” she added.The prime minister shared with the delegates one of her initiative to publish a series of book based on the intelligence reports, which were compiled against Bangabandhu during the pre-independence era, and the Agartala Conspiracy Case. This book would be very useful to learn about the country’s history and Bangabandhu’s relentless struggle for independence.Sheikh Hasina said Awami League would take part in the election in alliance with other friendly political parties. So Awami League leaders should be ready for sacrifice. Therefore, she said, all of you must work for the candidates whoever is given nomination from the party.last_img read more

BNP leaders discuss political rights issues at UN meeting

first_imgBNP leaders discuss political, rights issues at UN meetingA three-member team of Bangladesh Nationalist Party (BNP) on Thursday held a meeting with United Nations’ assistant secretary general for political affairs Miroslav Jenca to discuss the political and human rights issues of the country.BNP’s secretary general Mirza Fakhrul Islam Alamgir led the team during the hour-and-a-half meeting which began around 7:45pm (BDT) in New York.The BNP officials also held a 10-minute exclusive meeting with the UN official.BNP’s executive committee member Tabith Awal and BNP’s international affairs secretary Humayun Kabir were other members of the team.They discussed the next general elections with a five-member UN team, Fakhrul told the media after the meeting.The officials said the BNP leaders told the UN team that the AL government is going to hold another 5 January-like election. The BNP leaders wanted the UN to observe the next general elections.The BNP leaders also sought help from the UN to free the BNP chairperson Khaleda Zia.BNP officials also said BNP joined the meeting following an invitation from the UN secretary general Antonio Guterres.One of the BNP leaders who attended the meeting, told Prothom Alo that they particularly discussed the overall election and human rights issues.They told the UN representatives how the government has destroyed the fair procedure and peaceful atmosphere of the elections and also how it has threatened freedom of speech.They discussed the government’s reckless behaviour, role of the law enforcement, abductions, forced disappearances and arrests of their leaders and activists, and fake cases, the BNP leader added.New York BNP officials said Fakhrul is scheduled to fly to Washington from New York and then will return home.Incidentally, Oscar Fernandez Taranco, another assistant secretary general of the UN, visited Dhaka thrice between 2012 and 2013 to initiate a dialogue between the of Bangladesh Nationalist Party and Awami League leaders to minimise their political differences.During his visits, Taranco held a total of 25 meetings including with prime minister Sheikh Hasina, BNP chairperson and the former PM Khaleda Zia and the chief election commissioner.last_img read more

BNP to decide on joining polls after talks with Oikya Front

first_imgLogo of BNPBangladesh Nationalist Party (BNP) will hold talks with its ally Jatiya Oikya Front to reach a decision about contesting in the upcoming parliamentary polls and their next plan of action, according to a number of BNP senior leaders.The policymakers of the significant opposition are apparently in favour of joining in polls, the leaders say. “Whether the BNP will participate in the election or not, will be decided after discussing with Jatiya Oikya Front leaders shortly,” standing committee member Rafiqul Islam Miah told Prothom Alo.The election commission (EC) has announced the polls schedule on Thursday. The 11th national elections are scheduled for 23 December and the deadline for filing nomination papers is 19 November.According to the Representation of the People Order (RPO), a party has to inform the EC within three days after the announcement of election schedule if they are to contest in the polls as a coalition. Therefore, if Jatiya Oikya Front intends to participate in the polls, its allies have to submit applications to collect nominations by Sunday.Also, BNP will have to immediately decide who will accept the party’s assigned election symbol in the absence of its chairperson and acting chairperson. Notably, BNP’s chairperson Khaleda Zia has been in jail on graft charges while acting chairperson Tarique Rahman has been exiled in London.In this regard, the BNP will hold separate meetings with its 20-party alliances and standing committee members. Later, the senior BNP leaders may meet with Oikya Front leaders, according to BNP insiders.Also, BNP and Oikya Front may share their formal reaction about the polls schedule in a press briefing.Meanwhile, addressing the Jatiya Oikya Front rally held on Friday in Rajshahi, BNP’s general secretary Mirza Fakhrul Islam Alamgir said, the elections can only take place if Khaleda Zia is released, if equal rights are ensured for all political parties and if the election schedule is acceptable.last_img read more

US lawmakers challenge diversion of 1b for Trumps border wall

first_imgNew bollard-style US-Mexico border fencing is seen in Santa Teresa. Photo: ReutersA Democrat-led congressional committee challenged Tuesday the Pentagon’s plan to divert $1 billion to support President Donald Trump’s plan to build a wall on the US-Mexico border.Less than one day after acting Pentagon chief Patrick Shanahan authorized moving the funds from existing Defense Department projects to border construction, the House Armed Services Committee said this move was not permitted.It was the newest challenge to Trump’s February 15 declaration of a “national emergency” at the border in order to obtain more than $5 billion to build a frontier wall to keep out illegal immigrants and drug smugglers, after Congress denied him the funds.The Defense Department “is attempting to circumvent Congress and the American people’s opposition to using taxpayer money for the construction of an unnecessary wall, and the military is paying the cost,” said committee Chairman Adam Smith.”This needs to stop… The administration should stop using our service members as a political tool and instead focus on building military capabilities and readiness and areas where we should focus our defense resources.””Congress will act as necessary to defend its Constitutional prerogatives,” Smith warned in a statement.Late Monday, Shanahan said he had authorized the move of the funds to help the Homeland Security Department build 57 miles (92 kilometers) of 18-foot (5.5-meter) fencing, to construct and improve roads, and install lighting to support Trump’s emergency declaration.Addressing concerns that the US military was straying out of its mission into domestic civilian operations, Shanahan cited US law that authorizes the military to support the counterdrug activities of other federal agencies.For two years, Trump has battled Congress for as much as $25 billion in funds to fortify the Mexico border with a massive wall.After Congress voted earlier this month to nullify the emergency declaration, Trump vetoed it, allowing the Pentagon to reallocate billions of dollars to the border “emergency.”Smith said some limited amount of “reprogramming” of Pentagon funds for emergency needs without congressional approval is normally allowed.But the shift of $1 billion, he said, is “a violation of that trust.”The House of Representatives narrowly failed to override the veto as it did not reach the required two thirds of votes (288), falling short at 248.”Thank you to the House Republicans for sticking together and the BIG WIN today on the Border,” Trump said in response on Twitter.Court showdownThe emergency declaration has also been challenged in court by 16 states that contend that the order was contrary to Congress’s power over the budget.Their lawsuit also questioned Trump’s categorization of illegal border crossings as a national emergency, saying data issued by the administration itself refuted the notion.Should the states prevail, the case could work its way up to the Supreme Court, setting up a precedent-setting showdown on the separation of powers.last_img read more

6 Easy Tips to cure your skin dryness

first_imgPeople often complain of skin dryness and opt for varied beauty products to cure it. Avoiding long, hot shower bath or drinking at least two litres of water can help you rid the problem. Femalefirst.co.uk shares tips to take care of dry skin.Avoid long, hot shower bath – True, that hot water bath relieves stress but it can also make your skin dry. Hot water reduces natural oils from body much faster than lukewarm or cold water.Use a gentle cleanser or shower gel with moisturiser – Cleanser or nice shower gels make skin smoother and removes dryness. Also Read – ‘Playing Jojo was emotionally exhausting’Use good moisturiser – If face is moisturisd properly using a good moisturiser, it helps make skin soft and smooth. Moisturisers lock in moisture and help reduce dryness.Drink plenty of water – Experts recommended to drink two litres of water every day. Drinking plenty of water will ensure your body can produce  the minerals it needs to function properly. Eat healthy – Food items or ingredients like fish (salmon and sardines), flax and walnuts help maintain body’s natural oils. Eat food items, which contain Omega-3 acids that produce natural oil and minerals to keep your body healthy. Exfoliate – Dry skin can produce dead skin cells so it is important to exfoliate weekly to get rid of these cells so your body can produce new ones.last_img read more

Matter of excellence

first_imgThe tenth edition of Mahindra Excellence in Theatre Awards (META) is all set to celebrate the best of theatre and stagecraft. META provides a concrete platform to celebrate and promote theatre’s varied elements like playwriting, set design, costume and light design, direction and performance.  It aims at bringing together the best of Indian theatre from the year gone by. Nominations for this year’s edition have been declared which are handpicked from hundreds of entries by the jury that comprises stalwarts like Anup Hazarika, Deepa Punjani Krishnan, Sajitha Madathil, Sudhir Tandon and Vinod Nagpal. Also Read – ‘Playing Jojo was emotionally exhausting’The jury will pick winners in 13 categories including Best Play, Best Director, Best Stage Design, Best Light Design, Best Innovative Sound Design, Best Costume Design, Best Actor in a Lead Role (Male), Best Actor in a Lead Role (Female), Best Actor in a Supporting Role (Male), Best Actor in a Supporting Role (Female), Best Original Script, Best Ensemble, and Best Choreographer.A Straight Proposal directed by Happy Ranajit and produced by Unicorn’s Actor Studio  (Delhi, 1 Hour 45 Minutes, Hindi), Aaydaan directed by Sushma Deshpande and produced by Awishkar Theatre (Mumbai, 2 Hours 20 Minutes, Marathi), Chitrapata directed by Manjunath L Badiger and produced by Samasthi (Bengaluru, 85 Minutes, Kannada), Dhou… The Wave directed by Gunakar Dev Goswami  and produced by Purvarang  (Guwahati, 1 Hour 20 Minutes, Assamese), Dreams from my room directed by Chingtham Banikanta Singh and produced by Pan Manipuri Theatre  (Manipur, 50 Minutes, Manipuri), Fall of a King- Burha Manuhor Babe Desh Nai directed by Palash Protim Mech and produced by Oftas  (Assam, 1 Hour 20 Minutes, Assamese), Kaumudi directed by Abhishek Majumdar and produced by Riad Mahmood Education and Arts Foundation and Indian Ensemble  (Bengaluru, 2 Hours 5 Minutes, Hindi), Matthi directed by Jino Joseph and produced by Kathuparamba Malayakalanilayam  (Kerala, 1 Hour 30 Minutes, Malayalam), Rage and Beyond: Irawati’s Gandhari directed by Sanjukta Wagh and produced by Beej  (Mumbai, 65 Minutes, English), Still and Still Moving  directed by Neel Chaudhuri and produced by Tadpole Repertory  (Delhi, 95 Minutes, English, Hindi) are the plays that are nominated in the best plays category.The nominations for the best directors are – Happy Ranajit, Sushma Deshpande, Manjunath L Badiger, Gunakar Dev Goswami, Chingtham Banikanta Singh, Palash Protim Mech, Abhishek Majumdar, Jino Joseph, Sanjukta Wagh and Neel Chaudhuri. When: March 27 Where: The Taj Mahal Hotellast_img read more

JPMorgan Chase to Undergo Leadership Changes

first_img Jamie Dimon JPMorgan Chase Matthew Zames 2017-06-08 Staff Writer in Featured, Headlines, News Share JPMorgan Chase to Undergo Leadership Changescenter_img JPMorgan Chase COO Matthew Zames will be stepping down from his role after 13 years, the bank announced on Thursday.“While I am sad to see him leave, I respect his decision and all he has done for JPMorgan Chase,” JPMorgan Chairman and CEO Jamie Dimon said in a memo.According to the New York Times, Zames is leaving to start his own business. “I have been in this business almost 25 years. I spent the vast majority of my time running businesses, driving things forward, facing off against clients, taking business risk. But at its core, look: I’ll be 47 in October. I want to get back to running the railroad — running my railroad, running my business. So it’s just a natural point,” Zames said in an interview.Zames, 46, had a crucial role in guiding the bank during the financial crisis and is credited with raising suspicion over Bernie Madoff a year before his eventual arrest. Zames has long been assumed as a potential successor to Dimon, and the news of his stepping down has led to much speculation of who else may be in the running. A clue as to the frontrunners may be found in who will be taking over his duties during the transition. According to a report filed with the Securities and Exchange Commission, Zames’ responsibilities will be split between Marianne Lake, CFO; Daniel Pinto, CEO of Corporate & Investment Banking; Gordon Smith, CEO of Consumer & Community Banking, Mary Erdoes, CEO of Asset Management; and Doug Petno, CEO of the Commercial Bank, as follows:Marianne Lake: Assuming responsibility for the Chief Investment Office/Treasury, the Office of Regulatory Affairs, the Global Director of Regulatory Relations, Oversight and Controls, and Corporate FinanceDaniel Pinto and Gordon Smith: Assuming responsibility for Global Technology, the Intelligent Solutions group, and Mortgage Capital MarketsMary Erdoes and Doug Petno: Assuming responsibility of COO Global Operations unit, Global Real Estate, Global Security & Investigations, Military Affairs, Events Planning, Procurement, and other general services.In addition to these restructurings, Corporate Strategy and Private Investments will now report directly to Dimon. June 8, 2017 677 Views last_img read more

French quadplay operator Iliad Telecom has added

first_imgFrench quad-play operator Iliad Telecom has added 93,000 new subscribers to its Free service in the third quarter, which it said was attributable to the success of its advanced combined set-top and gateway, the Freebox Révolution.Iliad said it was achieving ARPU of €38 for Freebox Révolution subscribers, higher than its overall ARPU of €35.50, which was flat quarter-on-quarter.The 93,000 net additions to the Free brand included 20,000 migrations from Iliad’s other service, the former Telecom Italia France-owned Alice. Excluding former Alice subscribers, Free accounted for 27% of new subscribers in the French market in the course of the quarter. Free now counts 4.79 million subscribers, with a further 432,000 subscribers to the Alice brand.Iliad reported third quarter revenues of €537 million, up 5% year-on-year.last_img read more

Indian DTH pay TV operator DishTV has tapped techn

first_imgIndian DTH pay TV operator DishTV has tapped technology outfit MediaKind – formerly Ericsson Media Solutions – to provide its AVP 4000 video processing platform to deliver content to DishTV’s over 23.5 million subscribers.The AVP 4000 video processing platform exists within MediaKind’s Aquila family of solutions, which forms part of the wider MediaKind Universe portfolio.According to MediaKind, DishTV has selected its to replace its entire headend infrastructure, which includes existing legacy technology from its D2H brand.Anil DuaDishTV will operate MediaKind’s compression headend technology to deliver both traditional broadcast and multiscreen video from a single platform. That platform, which includes MediaKind’s AVP 4000 System Encoder, allows the operator to serve satellite operations for both of its brands, unifying the control and management of its two headends.Anil Dua, Group CEO, DishTV India Limited, said: “As a leading DTH provider in India, we are always looking for new ways to deliver a high quality viewing experience to our millions of customers. We are delighted to strengthen our longstanding partnership with MediaKind and leverage its compression technology heritage which extends more than 25 years. Through the deployment of MediaKind’s AVP technology, we can enable the highest video quality for our consumers alongside far greater bandwidth efficiencies, thus enabling us to cost-effectively deliver the next generation services to our subscribers.”Angel Ruiz, CEO, MediaKind, said: “The media landscape is constantly shifting and service providers need to continually adapt to deliver the highest quality media experiences for consumers. At the same time, the increased competition from pure-play online providers means it’s necessary to do this as cost-effectively as possible. We are delighted to extend our relationship with DishTV and to continue evolving its service offering in one of the world’s largest video markets. Through the deployment of our state-of-the-art AVP 4000 system, DishTV can potentially benefit from significant cost efficiencies and have the opportunity to launch new and highly compelling viewing experiences.”last_img read more

First off do you know what LNG stands for If you

first_imgFirst off, do you know what LNG stands for? If you answered “lots of natural gas,” you probably should spend the next three minutes of your life reading this missive. Then you can decide which side of the trade you want to be on. LNG stands for liquefied natural gas. Basically, a really smart nerd figured out how to compress natural gas by about 600 times by turning the gas into liquid. A lot of science went into this process, but we’re not going to cover all that in this article. So, let’s get in to what you really need to know about LNG. The first commercial LNG plant was built in the US in the 1940s, but LNG did not become important until the 1960s, when someone figured out how to ship the stuff across the world in specialized tankers. It was a big game changer, similar to how shale gas development has changed the natural gas paradigm. Now take LNG technology, partner it up with the shale revolution, and you get American LNG (ALNG). Made in the US, it’s better than the LNG in the rest of the world, right? That’s what Obamarama wants you to think. But we’ve dug up the truth, and you won’t want to miss it. Don’t believe everything (or anything) a politician tells you. The US is in big trouble, and there is not a chance that it will become energy self-sufficient by 2030. The next issue of the Casey Energy Report will cover the most important aspects of LNG – how it works, its dirty secrets, and the best part… how to make money from American LNG. We have at least three recommendations that subscribers can buy now to best position themselves to profit from the LNG boom. If you want to learn more about LNG than 99.999% of other investors, I highly recommend you take me up on my free trial offer to read the LNG report, and gain the knowledge that will help you profit in the energy sector today. Additional Links and Reads Earth May Have More Oil Than Anyone Thought (MSN Money) It is no surprise that as technology advances, so does the world’s oil and gas reserves. The discovery of shale gas is probably the essence of this fact, rewarding the United States with hundreds of trillions of cubic square feet of more natural gas. However, all the “easy” reserves have been exploited, and the world must now look toward unconventional and offshore resources. This means a lot higher costs, which in turn will mean higher energy prices. New South Wales Government Approval for Uranium Exploration a Step Closer (The Australian) Australia leads the world in uranium reserves, and it appears the country will utilize it, allowing exploration in the state of New South Wales (NSW). Australia is home to the Olympic Dam project, which is currently the second-largest producing mine in the world, and also hosts a staggering approximately 5.5 billion pounds of uranium resources. However, the expansion has been mired in delays and has run over budget. Could the exploration in NSW be an indication that Olympic Dam’s expansion will take much longer than expected? Greenpeace Finds Oil Muck in Russia (UPI) Russia has no incentive to adhere to strict environmental controls, as none of its consumers really care how the oil is extracted, as long as they have access to the oil. Meanwhile, the Canadian government recently axed Enbridge’s latest bid to construct a pipeline to the west coast, namely because of environmental concerns. This brings up an important question: Are environmentalists really looking out for what is best for the world, or just looking out for what is in their back yard? Canadian “maple leaf” oil adheres to the most stringent environmental policies in the world. More oil from Canada delivered around the world means that the planet is better off environmentally, especially when compared to Russian oil.last_img read more

Some of the worlds smartest investors are cutting

first_imgSome of the world’s smartest investors are cutting back on U.S. stocks…On Monday, Bloomberg Business reported that hedge fund managers cut their holdings in U.S. stocks by $200 billion last quarter. These funds now hold $1.5 trillion in U.S. stocks, down from $1.7 trillion at the end of June.The list of fund managers who trimmed their U.S. stock holdings reads like a “who’s who” of the investing world. It includes David Einhorn, John Burbank, David Tepper, and Stan Druckenmiller.Druckenmiller is one of the world’s most successful hedge fund managers. He generated an incredible 30% average annual return from 1986 to 2010. Today, he runs Duquesne Capital.At a conference earlier this month, Druckenmiller said he’s investing with caution right now.I’m working under the assumption that we may have started a primary bear market in July…I can see myself getting really bearish. I can’t see myself getting really bullish.Duquesne Capital cut its holdings of U.S. stocks by 41% last quarter, according to recent company filings.•  David Tepper cut his fund’s position in U.S. stocks by 30% last quarter…Tepper is the founder of Appaloosa Management, a $24 billion hedge fund that’s averaged 30% annual returns since 1993. That’s almost triple the S&P 500’s 11% return over the same period. Tepper has outperformed the market by nailing several “big picture” calls over his career.Tepper had been bullish on U.S. stocks since the global financial crisis. But he recently changed his stance. In September, Tepper told CNBC, “I can’t really call myself a bull.”According to Bloomberg, Appaloosa trimmed its holdings in U.S. stocks by 30% last quarter. The fund now holds $2.86 billion in U.S. stocks, its smallest stake since 2011…when the fund was 25% smaller.•  Tepper sees “all kinds of problems” in the market…Like us, Tepper believes U.S. stocks are too expensive. According to the popular CAPE valuation ratio, U.S. stocks are now 58% more expensive than their historic average.Tepper is also concerned about weak earnings growth. Earnings growth for companies in the S&P 500 has slowed six quarters in a row…As of last Friday, 90% of the companies in the S&P 500 had reported third-quarter results. Based on that data, research firm FactSet reports that S&P 500 companies’ earnings are set to drop 1.8% from last year.The S&P 500 is headed for its second straight quarter of falling earnings…which hasn’t happened since 2009. It means the U.S. stock market is on the verge of an “earnings recession.”Meanwhile, quarterly sales for S&P 500 companies are on track to fall for the third straight quarter. FactSet reports that third-quarter sales for companies in the S&P 500 have fallen 4% from last year. Recommended Links Can you legally remove yourself from U.S. tax code?70-year-old multimillionaire says “YES!” Click here to learn how to get the full story. – The Best Place to Hide Your MoneyIt’s tax-free. Pays up to 37 times more than bank accounts. And you DON’T NEED TO REPORT IT TO THE IRS. No wonder government doesn’t want you to know about this secret account. Click here to discover more… — •  The U.S. stock market is long overdue for a major pullback…The current bull market in U.S. stocks started in March 2009. It’s run for 80 months and counting. That’s 30 months longer than the average bull market since World War II.Bull markets don’t die of old age, but they all die eventually…The rally in U.S. stocks has already lost most of its momentum this year. The S&P climbed 204% from March 2009 through December 2014. But U.S. stocks have gone nowhere since. The S&P 500 is flat on the year.It takes a 20% decline to officially end a bull market. By that definition, this one isn’t technically over yet…though it took a big hit when the S&P 500 fell 11% in just six days in late August. Since then, U.S. stocks have recovered most of their losses, but have not made new highs.E.B. Tucker, editor of The Casey Report, thinks the bull market died during the mini-crash in August. E.B. shared that bold call with his readers in September.Last month’s major stock market decline is the start of a very tough time for stocks and the economy…The market has recovered in the past two weeks. But we think it’s only temporary. In other words, we’re in the middle of a “dead cat bounce.” It’s looking a lot like 2007.•  Meanwhile, demand for gold coins is skyrocketing…Sales of U.S. American Eagle gold coins hit a five-year high last quarter.The U.S. Mint produces various sizes of American Eagle coins. They’re the most popular gold coin in the United States.The chart below shows quarterly sales of American Eagles since 2009. The U.S. Mint sold over 12 tons of American Eagles last quarter. That’s the most it’s sold since the second quarter of 2010. It’s also 251% more than the U.S. Mint sold during the same quarter last year.The price of gold has declined 10% this year. The huge spike in American Eagle sales last quarter suggests investors are taking advantage of low prices to load up on physical gold.Casey readers know we think this is a smart approach. Gold is the ultimate form of financial wealth insurance. It’s preserved wealth through every kind of financial catastrophe imaginable. It will do the same thing when the next catastrophe hits…The U.S. stock market looks ripe for a major downturn. Valuations are stretched. Earnings and sales are dropping. And some of the smartest investors on the planet are scaling out of U.S. stocks.A stock market collapse in the coming months is a real possibility. If you don’t already hold a significant amount of gold, consider buying physical gold while it’s still cheap.Chart of the DayHere’s another reason to carefully assess your stock holdings…Today’s chart shows the level of margin debt for the New York Stock Exchange (NYSE). Margin debt is the value of stocks bought with borrowed money.As you can see, margin debt growth accelerated and peaked right before the last two major stock market crashes…Margin debt growth accelerated in the late 1990s. It peaked in March 2000, the same month the S&P 500 topped out. U.S. stocks went on to lose 37% during the dot-com bubble burst.Margin debt growth accelerated again in the mid-2000s. It peaked in July 2007, just three months before the S&P 500 topped out before the global financial crisis. Stocks went on to decline 57%.Margin debt also had a small run-up in 2011 before turning over that May. The S&P 500 peaked right around the same time. Then it declined 19.4%…stopping just short of the 20% threshold necessary to qualify as a bear market.In April, the level of margin debt for the NYSE hit an all-time high of $507 billion. In September, it fell for the third month in a row. The level of margin debt is now 11% below its April record high.At this point, it’s impossible to know for sure if the decline in margin debt is signaling an imminent downturn in stocks. However, we can tell you that the U.S. and global financial markets are far more fragile today than they were in 2011.Regards,Justin SpittlerDelray Beach, FloridaNovember 19, 2015We want to hear from you.If you have a question or comment, please send it to feedback@caseyresearch.com. We read every email that comes in, and we’ll publish comments, questions, and answers that we think other readers will find useful.last_img read more

Disabled people have spoken of their horror shock

first_imgDisabled people have spoken of their horror, shock and anger at learning of the vote to leave the European Union in last week’s referendum.Although many disabled people voted for Brexit, the vast majority of leading disabled activists were strongly in favour of remaining in the European Union.One disabled campaigner, who asked not to be named, said: “I think the majority of disability rights campaigners are in or recovering from shock.“There was a very strong campaign showing the benefits of EU membership to disability rights, but now that we have left the EU we know very little about what will happen next.“It feels like the carpet has been pulled out from underneath us and we’re not sure whether the bare boards we’re now looking at are stable.”In a blog for Disability Now, John Evans, one of the founders of the UK independent living movement, said the day of the referendum would “go down as the blackest day in the modern history for disabled people in the UK and for our human rights”.He said he was “dismayed, horrified and heartbroken about the consequences facing us and it is hard knowing which way to turn”.Miro Griffiths (pictured), a former project officer for the European Network on Independent Living (ENIL) and now a lecturer, researcher and teacher, said the vote meant that the connection between disabled people in the UK, their European supporters, policies “that reflect the aspirations of the independent living movement”, and “decision makers that would collaborate with us” had been “severely damaged – possibly beyond repair”.He said: “Disabled people in the UK will become further marginalised as the state begins to dismantle social justice frameworks and destroy the support systems that – currently – do not meet the needs of those who require them.“The most startling factor to consider is that the majority of those who voted unwittingly accepted this.”But Rick Burgess, of Manchester Disabled People Against Cuts, said: “I think it’s important not to let the fear and panic the media and politicians are spreading distract us from the fight that is the same today as it was before: to reclaim and reinforce our human rights.“That struggle is probably going to be harder now, so we have to both increase our resolve and to make sure we look after one another.“Our advantage is we have been fighting for many years already, we are seasoned and experienced survivors, we are ahead of many non-disabled people who are only now just waking up to the threat from the far right.”The disabled crossbench peer Lord Low told fellow members of the House of Lords that there was a strong case for a second referendum, as called for in a petition on parliament’s website that by last night (Wednesday) had secured more than four million signatures.He said he believed the “leave” campaign had won the vote on what was “an essentially fraudulent prospectus”.He said: “They said that we could continue to trade with the EU on very similar terms without having to accept freedom of movement.“They said that there would be no adverse economic consequences, but we are already beginning to see them.“They made completely unrealistic promises as to what could be done with the resources saved from our EU contribution, and, most glaringly of all, with breath-taking cynicism and within hours of victory they were maintaining that they never said that Brexit would enable them to reduce the level of immigration.”The referendum result drew immediate support for disabled people in the UK from the two main Europe-wide disabled people’s organisations, the European Disability Forum (EDF) and ENIL.ENIL said it felt “sadness, disbelief and dejection” at the vote, emotions which it said were shared with the UK independent living and disability rights movements.It said: “We are deeply concerned about the prospect of disabled people in Britain being worse off and hit by further cuts.“Although discrimination and inequality affect many disabled people throughout Europe, there are numerous EU initiatives that have had a positive impact on our lives and have created a stronger legal basis to protect our rights.”It said it would “not leave our British disabled brothers and sisters behind and will do everything in our power to support them in their fight for independent living”.It added: “ENIL respects the democratic right of the British people to decide on their EU membership.“However, we are adamant that a strong human rights agenda throughout Europe is better achieved together.“ENIL will continue and intensify its collaboration with disabled people in the UK.”EDF said it accepted the result of the referendum with “regret”, and also promised to continue to work with disabled people’s organisations in the UK.Yannis Vardakastanis, EDF’s president, said: “EDF will continue to promote unity and solidarity within the disability movement all across Europe and will work very decisively on our common values against Euroscepticism, xenophobia, racism and all kinds of discrimination.“From this, we won’t exclude any people with disabilities or their organisations because of political choices.“We will collaborate with all organisations of persons with disabilities in Europe, including the UK, to ensure that Europe does not lose sight of the importance of human rights of all of its people: women, men, children, older people, persons with disabilities and people on the move across Europe and on our borders.”last_img read more

4 Novel Trademark Developments We Saw in 2017

first_imgTrademarks 4 Novel Trademark Developments We Saw in 2017 December 26, 2017 Apply Now » The only list that measures privately-held company performance across multiple dimensions—not just revenue. Jaia Thomas Image credit: Michael Zagaris | Getty Images –shares Next Article Attorney and Entrepreneur 2019 Entrepreneur 360 List Current events quickly morph into trademarking sprees seeking to capitalize on what’s in the news. Guest Writer Add to Queue 3 min read To date, 594,107 trademark applications were filed with the United States Patent and Trademark Office (USPTO) this year, which is a 12 percent increase from last year. Here are some of the most interesting trademark trends of 2017:Make America…In 2015 the non-profit organization, Donald J. Trump for President, registered the phrase “Make America Great Again” as a federal trademark with the USPTO. This year hundreds of people decided to take Trump’s trademark and add their own twist to it.Related: President Trump Does This Every Morning — and There’s a Scientific Reason You Should, TooCurrently, there are over 150 active or pending trademarks with the phrase “Make America.” Some trademark applications that were submitted this year include: “Make America Date Again,” “Make America Thin Again,” “Make America Fresh Again” and “Make America Smart Again.” Take a knee.For the better part of 2017, debate and controversy surrounding the NFL national anthem boycott dominated the news. Several key phrases were born out of this movement, including the phrase “Take A Knee.” Over the past couple of months, two individuals filed trademark applications to register the phrase “Take a Knee.” And recently, an individual in New York filed an application to register the phrase “Take a Knee America.”Overall, there has been a surge in the number of trademark applications protecting slogans and phrases birthed out of protest movements (e.g. applications were also filed for such phrases “Women’s March” and “Proud to Protest”).Related: Transgender Rights? Citizens United? Should Brands Get Political?The Slants.For years the Asian-American rock band, The Slants, fought for the right to trademark their band name. The USPTO had adamantly opposed registering the name citing the Lanham Act, which prohibits the registration of any trademark that could “disparage or bring into contempt or dispute any persons living or dead.”This summer, the United States Supreme Court overruled the USPTO’s finding and allowed the group to move forward with registration. Since the ruling, there has been an uptick in the number of trademark applications that include or describe a racial trait or characteristic. Some recent trademark applications include: “Proud to be Latino” and “Harmless Black Man.”Social media icons.While many social media platforms, such as Instagram and Twitter, began trademarking their company names years ago, this year was the year they finally began to receive registration certificates for their icons.Related: What Is a Logo? Just the Beating Heart of Your Brand, That’s All.Instagram currently owns trademarks for their name as well for all their filters, such as Sierra and Hudson, and for their such abbreviations such as “Insta.” But, this year their camera icon was formally registered as trademark and so was Facebook’s thumbs-up like button. Facebook currently has 121 active or pending trademarks whereas Instagram currently has 75 active or pending trademarks. Opinions expressed by Entrepreneur contributors are their own.last_img read more

Adolescents who use cognitive reappraisal had better metabolic measures shows study

Reviewed by James Ives, M.Psych. (Editor)Dec 14 2018Most teens get stressed out by their families from time to time, but whether they bottle those emotions up or put a positive spin on things may affect certain processes in the body, including blood pressure and how immune cells respond to bacterial invaders, according to Penn State researchers.The researchers explored whether the strategies adolescents used to deal with chronic family stress affected various metabolic and immune processes in the body. Strategies could include cognitive reappraisal — trying to think of the stressor in a more positive way — and suppression, or inhibiting the expression of emotions in reaction to a stressor.The team found that when faced with greater chronic family stress, teens who used cognitive reappraisal had better metabolic measures, like blood pressure and waist-to-hip ratio. Teens who were more likely to use suppression tended to have more inflammation when their immune cells were exposed to a bacterial stimulus in the lab, even in the presence of anti-inflammatory signals.Hannah Schreier, assistant professor of biobehavioral health at Penn State, said the results suggest that the coping skills teens develop by the time they are adolescents have the potential to impact their health later in life.”These changes are not something that will detrimentally impact anyone’s health within a week or two, but that over years or decades could make a difference,” Schreier said. “That may be how small changes in metabolic or inflammatory outcomes may become associated with poorer health or a greater chance of developing a chronic disease later in life.”Emily Jones, graduate student in biobehavioral health at Penn State, said the results — recently published in Psychosomatic Medicine — help therapists and counselors better work with children and adolescents who live in stressful environments.”Exposure to chronic stress doesn’t always lead to poorer health outcomes, in part because of differences among people,” Jones said. “As our study findings suggest, there may be ways to help someone be more resilient in the face of stress by encouraging certain emotion regulation strategies. For children in stressful living situations, we can’t always stop the stressors from happening, but we may be able to help youth deal with that stress.”Although previous research has linked chronic stress during childhood with such conditions as depression, autoimmune disorders and cardiovascular disease, the researchers said less is known about why some people under chronic stress develop these conditions while others do not. While it was thought that emotional regulation may play a role, the researchers were not sure exactly how.Related StoriesUTHealth researchers investigate how to reduce stress-driven alcohol useTransobturator sling surgery shows promise for stress urinary incontinenceNew ACC/AHA guidelines could improve detection of gestational hypertensionTo better explore how different ways of regulating emotions can affect different aspects of physical health, the researchers gathered data from 261 adolescents between the ages of 13 and 16 years.The researchers interviewed the participants about the relationships and chronic stress within their families, as well as measured the participants’ waist-to-hip ratios and blood pressure. The adolescents also completed questionnaires about how they regulated their emotions.To measure immune function, the researchers took blood samples from each participant and exposed the blood to a bacterial stimulus — both with and without the anti-inflammatory substance hydrocortisone — to see how the immune cells would respond.The researchers found that under conditions of greater chronic family stress, the immune cells of adolescents who were more likely to use suppression also tended to produce more pro-inflammatory cytokines, molecules that signal to other cells that there is a threat present and that the body’s immune system needs to kick into gear.The cells of these teens produced more cytokines even in the presence of hydrocortisone, an anti-inflammatory substance that usually tells the body to slow down on producing cytokines.”Cytokines are like messengers that communicate to the rest of the body that added support is needed,” Jones said. “So when you have a high level of these pro-inflammatory cytokines, even in the presence of anti-inflammatory messages from cortisol, it may suggest that your body is mounting an excessive inflammatory response, more so than necessary. It suggests that the immune system may not be functioning as it should be.”Meanwhile, the researchers found that adolescents who tended to use cognitive reappraisal while under more family stress had smaller waist-to-hip ratios — a measurement used as an indicator of health and chronic disease risk — and lower blood pressure.”While we would have to follow up with more studies, the results could lend support to the idea that reappraising a situation during times of stress could be beneficial,” Jones said. “For a mild stressor, this could be as simple as reframing a bad situation by thinking about it as a challenge or an opportunity for growth.”The researchers added that opportunities for future studies could include looking at the effects of emotion regulation strategies on these metabolic and immune measures over time to tease apart how the family environment shapes emotion regulation, how emotion regulation may itself influence stress exposure, and how chronic family stress and emotion regulation together can affect chronic disease risk in the long run.Source: https://news.psu.edu/ read more

Neuroscientists decipher how brain circuits optimize themselves

first_imgReviewed by James Ives, M.Psych. (Editor)Jan 2 2019Human beings, like other animals, possess an enormous learning capacity that allows for the apprehension of new sensory information to master new skills or to adapt to an ever-changing environment. However, many of the mechanisms that enable us to learn remain poorly understood. One of the greatest challenges of systems neuroscience is to explain how synaptic connections change to support adaptive behaviors. Neuroscientists at the University of Geneva (UNIGE), Switzerland, previously showed that synaptic learning mechanisms in the brain’s cortex are dependent on feedback from deeper brain regions. They have now precisely deciphered how this feedback gates synaptic strengthening by switching on and off particular inhibitory neurons. This study, which can be read in Neuron, not only constitutes an important milestone in our understanding of the mechanisms for perceptual learning but may also offer insight into computerized learning systems and artificial intelligence.The cortex – the brain’s outer and largest region – is important for higher cognitive functions, complex behaviors, perception, and learning. Upon the arrival of a sensory stimulus, the cortex processes and filters its information before it passes the most relevant aspects on to other brain regions. Some of these brain regions, in turn, send information back to the cortex. These loops, known as “feedback systems”, are thought to be essential for the functioning of cortical networks and their adaptation to new sensory information. “For perceptual learning – which is the improved ability to respond to a sensory stimulus – neuronal circuits need to first assess the importance of the incoming sensory information and then refine the way it is processed in the future. Feedback systems to a degree confirm that those synapses that were responsible for transmitting the information to other brain areas did this correctly”, explains Anthony Holtmaat, professor in basic neurosciences at the UNIGE Faculty of Medicine, who directed this study.How the whiskers highlight the feedback systemsThe whiskers on a mouse’s snout are specialized in tactile sensing and play a major role in the animal’s ability to comprehend aspects of its direct environment. The part of the cortex that processes sensory information from the whiskers continuously optimizes its synapses in order to learn new aspects about the tactile environment. Therefore, it constitutes an interesting model for understanding the role of feedback systems in synaptic learning mechanisms.The UNIGE scientists isolated a whiskers-related feedback circuit, and used electrodes to measure the electrical activity of neurons in the cortex. They then mimicked the sensory input by stimulating a specific part of the cortex known for processing this information, and, at the same time, used light to control the feedback circuit. “This ex vivo model allowed us to control the feedback independently from the sensory input, which is impossible to do in vivo. However, disconnecting the sensory input from the feedback was essential to understanding how the interplay between the two leads to synaptic strengthening” adds Holtmaat.Inhibiting neurons gate the informationRelated StoriesWearing a hearing aid may mitigate dementia riskRepurposing a heart drug could increase survival rate of children with ependymomaDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustThe team found that both components, when triggered separately, activate a wide range of neurons. However, when activated simultaneously, some neurons actually decrease their activity. “Interestingly, the neurons that are inhibited when the sensory input and the feedback occur together usually inhibit neurons that are important for perception, this is known as an inhibition of inhibition or a disinhibition”, explains Leena Williams from the UNIGE Faculty of Medicine, the study’s first author. “Thus, these neurons act like a gate for the incoming information, and which is normally closed. But when feedback comes in, the gate is opened, allowing those synapses that take care of the primary sensory information to increase their strength. With this study we have identified how feedback possibly optimizes synaptic connections to better prepare for future incoming information”, she adds.Now that they have precisely identified which neurons are involved in this mechanism, these scientists will test their results in “real life” to check whether the inhibiting neurons will behave as predicted when a mouse needs to learn new sensory information or when it discovers new aspects in its tactile environment.Deep learning: mimicking natural intelligenceHow do brain circuits optimize themselves? How can a system teach itself by reading out its own activity? Apart from being relevant to learning in animals, this question is also at the heart of machine learning programs. Indeed, some deep learning specialists try to mimic brain circuits to build artificially intelligent systems. Insights such as provided by the UNIGE team might be relevant for unsupervised learning, a branch of machine learning that occupies itself with circuit models that are able to self-organize and optimize the processing of new information. This is important for the creation of efficient voice or face recognition programs, for example. Source:https://www.unige.ch/en/last_img read more

Mice sleeping fitfully help unravel mystery of insomnia

first_img Source:https://medicine.wustl.edu/news/mice-sleeping-fitfully-provide-clues-to-insomnia/ Reviewed by Kate Anderton, B.Sc. (Editor)Jan 9 2019Genetically engineered mice mimic common sleep problemsMice that sleep fitfully could help researchers unravel the mystery of insomnia.Researchers at Washington University School of Medicine in St. Louis studied mice genetically modified to mimic the genetic disease neurofibromatosis type 1 (NF1), which is associated with sleep problems. They found that the animals, like some people with NF1, slept in short, irregular spurts. Studying these mice could help identify the molecular and cellular mechanisms that go awry and cause fragmented sleep patterns in people with and without the disease, the researchers said.”The mice are a tool for us to understand how sleep disturbances arise and how sleep disruption contributes to problems with learning and attention,” said David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor of Neurology and the study’s senior author. “This could apply both to people with NF1 and others without NF1 who also have sleep problems.”The findings were published Jan. 4 in the Journal of Sleep Research.As many as half of people with NF1 – a condition that causes benign tumors in the brain and on nerves throughout the body – have difficulty falling or staying asleep. Learning disabilities and attention problems also are common in children with NF1, and both may be exacerbated by poor sleep. But doctors don’t know why some children with NF1 develop sleep problems and others don’t, nor can they do much to help them sleep better.”Right now we just treat children and adults with NF1 and sleep problems like we treat patients without NF1 because we don’t understand what causes them,” said Gutmann, who also directs the Neurofibromatosis Center at Washington University.Related StoriesPoor sleep associated with high blood pressureCBT for insomnia delivered via telemedicine is as effective as face-to-face deliveryUnpleasant experiences could be countered with a good night’s REM sleepCo-first author Corina Anastasaki, PhD, an instructor in neurology, bred mice with a mutation in their Nf1 gene similar to what is seen in people with NF1. Then, co-first author Nicholas Rensing and Michael J. Wong, MD, PhD, the Allen P. and Josephine B. Green Professor of Pediatric Neurology, fitted onto the mice miniature versions of the caps people wear for sleep studies, enabling them to measure brain waves and identify sleep patterns.Mice normally sleep during the day and, like people, cycle several times from deep, dreamless sleep to REM sleep – or dreaming – and back again. Mice with an Nf1 mutation, however, tended to wake up soon after they entered deep sleep. The result was a fragmented, and probably not restful, day of sleep.”Throughout the whole night and day, they fell asleep and woke up when they shouldn’t have,” Anastasaki said. “They fell into deep sleep, but they didn’t stay there.”Although the mice were engineered to mimic human NF1 disease, they could yield insights about the biological underpinnings of sleep in general, which could help people with sleep problems unrelated to NF1. About a third of American adults report some degree of insomnia, and 15 percent have chronic insomnia that lasts three months or more.”It is hard to study sleep problems in people because there are so many factors that influence how well you sleep – maybe you’re stressed out, maybe you’re sick, maybe you’re taking care of a new baby,” Gutmann said. “But now we have a controlled system that we can use to start looking at which cells and proteins are involved, and which biological factors influence sleep quality. Only when we understand the problem better will we be able to find better ways to treat it.”last_img read more